منابع مشابه
Heparin Action
THE OBJECTIVE of this editorial is to describe recent progress in our understanding of the biochemical mechanism of heparin's anticoagulant action and to consider ways in which this new knowledge may alter our current methods of monitoring heparin therapy. During the coagulation of blood, thrombin is produced from its precursor, prothrombin, by the concerted action of Factor V and activated Fac...
متن کاملHeparin action.
THE OBJECTIVE of this editorial is to describe recent progress in our understanding of the biochemical mechanism of heparin's anticoagulant action and to consider ways in which this new knowledge may alter our current methods of monitoring heparin therapy. During the coagulation of blood, thrombin is produced from its precursor, prothrombin, by the concerted action of Factor V and activated Fac...
متن کاملThe antimicrobial action of heparin.
The earliest report on the bacteriostatic effect of heparin was made by Stoker (1949) who claimed that Staphylococcus aureus was inhibited by heparin only in the presence of protein (pus or trauma blood). Later Warren and Graham (1950) found, in contradistinction to the results of Stoker (1949), that Bacterium 8tewartii and Micrococcus pyogens var. aureus were not inhibited by heparin when grow...
متن کاملHeparin and low-molecular-weight heparin: mechanisms of action, pharmacokinetics, dosing, monitoring, efficacy, and safety.
Abbreviations: ACT 5 activated clotting time; APTT 5 activated partial thromboplastin time; AT 5 antithrombin; AT-III 5 antithrombin III; CI 5 confidence interval; DVT 5 deep vein thrombosis; GP 5 glycoprotein; HIT 5 heparininduced thrombocytopenia; INR 5 international normalized ratio; LMWH 5 low-molecular-weight heparin; MI 5 myocardial infarction; NQMI 5 non-Q-wave myocardial infarction; OR ...
متن کاملHeparin-catalyzed inhibitor/protease reactions: kinetic evidence for a common mechanism of action of heparin.
Three different heparin-catalyzed inhibitor/protease reactions were studied: antithrombin III/thrombin, heparin cofactor II/thrombin, antithrombin III/factor Xa. The three reactions were saturable with respect to both inhibitor and protease. The initial reaction velocity, for each reaction, could be described by the general rate equation for a random-order bireactant enzyme-catalyzed reaction. ...
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ژورنال
عنوان ژورنال: Circulation
سال: 1974
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.49.4.603